Map - Mendrisio (district) (Mendrisio District)

The Mendrisio District (Distretto di Mendrisio, also called Mendrisiotto) is the southernmost district of canton of Ticino and of Switzerland. To its north lies the Lugano District. It is surrounded on the other three sides by Italy: to the east and south by the province of Como, and to the west by the province of Varese. It has a population of (as of ).

The Mendrisio District has an area,, of 100.89 km2. Of this area, 25.79 km2 or 25.6% is used for agricultural purposes, while 61.2 km2 or 60.7% is forested. Of the rest of the land, 18.88 km2 or 18.7% is settled (buildings or roads), 0.44 km2 or 0.4% is either rivers or lakes and 0.99 km2 or 1.0% is unproductive land.

Of the built up area, industrial buildings made up 2.0% of the total area while housing and buildings made up 9.7% and transportation infrastructure made up 5.3%. Power and water infrastructure as well as other special developed areas made up 1.1% of the area Out of the forested land, 57.0% of the total land area is heavily forested and 3.6% is covered with orchards or small clusters of trees. Of the agricultural land, 11.9% is used for growing crops, while 4.0% is used for orchards or vine crops and 9.7% is used for alpine pastures. All the water in the district is flowing water.